Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ InSolution™ PTP1B Inhibitor
The InSolution™ PTP1B Inhibitor controls the biological activity of PTP1B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ ApoE4 Modulator, PH002
A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby reversing the detrimental effects of ApoE4.
MilliporeSigma™ Calbiochem™ DL-threo-PDMP, Hydrochloride
PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.
MilliporeSigma™ Calbiochem™ Glucagon Receptor Antagonist II
The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.
MilliporeSigma™ Calbiochem™ Granzyme B Substrate II, Fluorogenic
A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.
MilliporeSigma™ Calbiochem™ HIF Inhibitor VII
A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B
MilliporeSigma™ Calbiochem™ Gemcitabine, HCl
A bioavailable, moderately toxic, deoxyctytidine analog with anti-metabolite and anti-tumor properties
MilliporeSigma™ Calbiochem™ EIF2AK3 Activator, CCT020312
The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.
MilliporeSigma™ Calbiochem™ Kir6.2/SUR1 Channel Activator, VU0071063
A fast acting, reversible, and selective activator of Kir6.2/SUR1 channels (EC50 = 7 μM).
MilliporeSigma™ Calbiochem™ AKR1C3 Inhibitor
The AKR1C3 Inhibitor controls the biological activity of AKR1C3.
MilliporeSigma™ Calbiochem™ Necrostatin-1, Inactive Control
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
MilliporeSigma™ Calbiochem™ PDGFR Tyrosine Kinase Inhibitor IV
A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33
MilliporeSigma™ Calbiochem™ Cdc42/Rac1 Dual Inhibitor, AZA1
A cell-permeable compound that suppresses upregulation of GTP-bound Rac1 and Cdc42. Inhibits prostate cancer cells migration by decreasing cellular F-/G-actin ratio.
MilliporeSigma™ Calbiochem™ LSF Inhibitor, FQI1
The LSF Inhibitor, FQI1 controls the biological activity of LSF.
MilliporeSigma™ Calbiochem™ PknG Inhibitor
The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.